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Updated: Apr 25, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

Nuzhat N Kabir1, Jianmin Sun, Lars Rönnstrand

  • 1Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|August 31, 2014
PubMed

Insights

Suppressors of cytokine signaling 6 (SOCS6) negatively regulates receptor tyrosine kinase signaling by promoting protein degradation and apoptosis. SOCS6 downregulation in cancers highlights its role in survival signaling.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • Suppressors of cytokine signaling (SOCS) proteins are key negative regulators of cytokine receptor signaling.
  • SOCS6, a member of the SOCS family, uniquely targets receptor tyrosine kinase signaling pathways.
  • SOCS6 protein structure includes an N-terminal region, SH2 domain, and SOCS box.

Purpose of the Study:

  • To elucidate the specific role of SOCS6 in receptor tyrosine kinase signaling.
  • To investigate the mechanisms by which SOCS6 regulates cell survival and apoptosis.
  • To examine the implications of SOCS6 downregulation in various human cancers.

Main Methods:

  • Analysis of SOCS6 expression patterns in different tissues and cancer types.
  • Investigation of SOCS6's role in protein ubiquitination and degradation pathways.
  • Assessment of SOCS6's impact on apoptosis induction via mitochondrial pathways.

Main Results:

  • SOCS6 is widely expressed but downregulated in numerous cancers, including colorectal, gastric, and lung cancer.
  • SOCS6 mediates negative regulation of receptor signaling through enhanced ubiquitination and degradation of receptors and substrates.
  • SOCS6 induces apoptosis by targeting mitochondrial proteins, thus acting as a regulator of survival signaling.

Conclusions:

  • SOCS6 is a critical negative regulator of receptor tyrosine kinase signaling.
  • SOCS6's tumor-suppressive activity is linked to its role in promoting protein degradation and apoptosis.
  • Restoring SOCS6 activity may offer therapeutic potential for various cancers characterized by its downregulation.

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