A review on lecithin:cholesterol acyltransferase deficiency
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Updated: Oct 24, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Ramesh Saeedi1, Min Li1, Jiri Frohlich1
1Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Abstract:
Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal opacities, changes in erythrocyte morphology and renal failure. Recombinant LCAT is being developed for the treatment of patients with LCAT deficiency.
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