Effect of sleeve gastrectomy on thyroid hormone levels

Area of Science:

• Endocrinology
• Bariatric Surgery
• Metabolic Health

Background:

• Weight loss in morbid obesity impacts thyroid function.
• Previous bariatric surgeries (LRYGB, BPD, LAGB) show thyroid function alterations.
• No prior data exists on thyroid function changes post-LSG.

Purpose of the Study:

• To evaluate thyroid function changes (TSH, FT4) after LSG in euthyroid patients.
• To assess the relationship between thyroid hormone changes, excess weight loss (EWL), and baseline TSH.

Main Methods:

• Retrospective analysis of prospectively collected LSG patient data.
• Evaluation of TSH and FT4 levels 6-12 months post-LSG.
• Correlation analysis with EWL and baseline TSH.

Main Results:

• Mean BMI significantly decreased post-LSG (42.4 to 32.5 kg/m²).
• Mean TSH levels decreased significantly (2.45 to 1.82 mU/L).
• Mean FT4 levels remained unchanged; TSH decrease correlated with baseline TSH but not EWL.

Conclusions:

• LSG causes a decrease in TSH and stable FT4 levels in euthyroid patients.
• These thyroid function changes are comparable to those observed after LRYGB.
• The mechanism behind TSH reduction post-LSG requires further investigation.