Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.7K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.5K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.5K
Embryonic Stem Cells00:58

Embryonic Stem Cells

25.7K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
25.7K
Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.7K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiation and functionality of human bronchial epithelial cells in an air-liquid interface culture are modified by irradiation exposure.

Frontiers in public health·2026
Same author

Relative biological effectiveness and neural stem cell fate in carbon ion-irradiated human brain organoids.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting.

iScience·2025
Same author

Aberrant choroid plexus formation drives the development of treatment-related brain toxicity.

Communications biology·2025
Same author

Human cerebral organoids model tumor infiltration and migration supported by astrocytes in an autologous setting.

bioRxiv : the preprint server for biology·2025
Same author

MatriGrid<sup>®</sup> Based Biological Morphologies: Tools for 3D Cell Culturing.

Bioengineering (Basel, Switzerland)·2022
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Apr 25, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K

Stem cells: are we ready for therapy?

Insa S Schroeder1

  • 1Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Planckstr. 29, 64291, Darmstadt, Germany, i.schroeder@gsi.de.

Methods in Molecular Biology (Clifton, N.J.)
|September 1, 2014
PubMed
Summary
This summary is machine-generated.

Cell therapy utilizes stem cells for regenerative medicine, reviewing progress from research to pharmaceutical manufacturing. Adult stem cells, embryonic stem (ES) cells, and induced pluripotent stem (iPS) cells are compared, alongside commercialization challenges.

More Related Videos

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

7.4K
Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

10.5K

Related Experiment Videos

Last Updated: Apr 25, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K
Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

7.4K
Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

10.5K

Area of Science:

  • Regenerative Medicine
  • Cell Therapy
  • Stem Cell Biology

Background:

  • Cell therapy is a cornerstone of regenerative medicine, aiming to replace diseased or damaged cells.
  • Stem cells, including adult, embryonic stem (ES), and induced pluripotent stem (iPS) cells, are central to therapeutic applications.
  • Translating basic stem cell research into scalable pharmaceutical manufacturing is crucial for clinical success.

Purpose of the Study:

  • To review the progress in translating stem cell research into pharmaceutical manufacturing processes.
  • To compare the therapeutic applications and potential of adult stem cells versus ES and iPS cells.
  • To highlight the scientific, technical, and economic challenges in commercializing stem cell therapies and in vitro models.

Main Methods:

  • Literature review of stem cell research translation and pharmaceutical manufacturing.
  • Comparative analysis of adult stem cells, ES cells, and iPS cells for therapeutic use.
  • Discussion of challenges in developing and commercializing stem cell-based products.

Main Results:

  • Significant progress has been made in translating stem cell research into manufacturing.
  • Adult stem cells have a long history of therapeutic use, while ES and iPS cells offer future potential.
  • Commercialization faces substantial scientific, technical, and economic hurdles.

Conclusions:

  • Stem cell therapy is advancing, with ongoing efforts to bridge research and manufacturing.
  • A comprehensive understanding of different stem cell types is vital for therapeutic development.
  • Overcoming commercialization challenges is key to realizing the full potential of stem cell-based regenerative medicine.