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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
A chimeric mouse model to study immunopathogenesis of HCV infection
Moses T Bility1, Anthony Curtis, Lishan Su
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 7295, Chapel Hill, NC, 27599, USA, moses_bility@med.unc.edu.
Abstract:
Several human hepatotropic pathogens including chronic hepatitis C virus (HCV) have narrow species restriction, thus hindering research and therapeutics development against these pathogens. Developing a rodent model that accurately recapitulates hepatotropic pathogens infection, human immune response, chronic hepatitis, and associated immunopathogenesis is essential for research and therapeutics development. Here, we describe the recently developed AFC8 humanized liver- and immune system-mouse model for studying chronic hepatitis C virus and associated human immune response, chronic hepatitis, and liver fibrosis.
