A highly efficient group-assisted purification method for the synthesis of poly-functionalized
Yuvaraj Dommaraju1, Dipak Prajapati
1Medicinal Chemistry Division, CSIR-North-East Institute of Science and Technology, Jorhat, 785006, Assam, India.
Abstract:
A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.
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