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Updated: Apr 25, 2026
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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
Published on: December 18, 2013
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Control of systemic proteostasis by the nervous system
Pablo Mardones1, Gabriela Martínez1, Claudio Hetz2
1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Trends in Cell Biology
|September 2, 2014
Summary
Cellular proteostasis is maintained through neuron-to-organ communication. Protein-folding stress in neurons triggers adaptive programs in peripheral organs, highlighting cell-nonautonomous proteome maintenance.
Area of Science:
- Physiology
- Cell Biology
- Neuroscience
Background:
- Organismal homeostasis relies on integrating internal and external signals to detect molecular changes.
- Studies in model organisms reveal communication between neuronal alarm pathways and peripheral organs during protein-folding stress.
Purpose of the Study:
- To review emerging concepts on the proteostasis network's role in animal physiology.
- To highlight how the proteostasis network integrates signals across tissues for cellular proteostasis.
Main Methods:
- Review of recent findings and emerging concepts in the field.
- Analysis of studies focusing on inter-organ communication and proteostasis.
Main Results:
- The proteostasis network contributes to regulating animal physiology through inter-tissue signal integration.
- Neuronal protein-folding stress can activate adaptive programs in peripheral organs.
- A novel layer of cell-nonautonomous functional interrelation orchestrates proteome maintenance at the organismal level.
Conclusions:
- The proteostasis network plays a crucial role in maintaining organismal homeostasis.
- Cell-nonautonomous communication is vital for global proteome maintenance.
- Understanding these inter-organ communications offers new insights into physiology and disease.
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