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Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
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Cluster-determinant 36 (CD36) impacts on vitamin E postprandial response.

Aurélie Goncalves1, Stéphanie Roi, Marion Nowicki

  • 1INRA, UMR 1260, Nutrition, Obesity and Risk of Thrombosis, Marseille, France; INSERM, UMR 1062, Marseille, France; Aix-Marseille Université, Marseille, France.

Molecular Nutrition & Food Research
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PubMed
Summary

Cluster determinant 36 (CD36) plays a role in vitamin E uptake. CD36 influences postprandial lipid metabolism, which in turn affects vitamin E response.

Keywords:
BioavailabilityCD36Intestinal absorptionTransgenic miceα-Tocopherolγ-Tocopherol

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nutritional Science

Background:

  • A single nucleotide polymorphism in the cluster determinant 36 (CD36) gene is linked to plasma α-tocopherol levels.
  • This suggests CD36 may be involved in vitamin E absorption or tissue uptake.

Purpose of the Study:

  • To investigate the role of CD36 in vitamin E transport.
  • To evaluate CD36's effect on α- and γ-tocopherol uptake and efflux.
  • To assess γ-tocopherol postprandial response in CD36-deficient mice.

Main Methods:

  • Utilized transfected HEK cells to assess transmembrane uptake and efflux of α- and γ-tocopherol.
  • Assessed postprandial γ-tocopherol response in CD36-deficient and wild-type mice.
  • Characterized plasma and tissue levels of α-tocopherol, vitamin A, and lipids in mice.

Main Results:

  • Overexpression of CD36 significantly increased both α- and γ-tocopherol uptake in HEK cells.
  • CD36-deficient mice showed decreased hepatic cholesterol and increased triacylglycerol content in multiple tissues (males).
  • While tissue α-tocopherol concentration (lipid-adjusted) was unchanged, γ-tocopherol postprandial response was elevated in CD36-deficient mice.

Conclusions:

  • CD36 directly or indirectly participates in vitamin E uptake.
  • CD36's influence on postprandial lipid metabolism impacts vitamin E's postprandial response.