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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Bottom-up and Shotgun Proteomics to Identify a Comprehensive Cochlear Proteome

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Published on: March 7, 2014

Defining the human gallbladder proteome by transcriptomics and affinity proteomics.

Caroline Kampf¹, Adil Mardinoglu, Linn Fagerberg

¹Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

|September 2, 2014

Summary

This summary is machine-generated.

This study identifies 140 gallbladder-specific proteins using deep RNA sequencing and immunohistochemistry. These proteins are crucial for understanding gallbladder physiology and metabolic functions.

Keywords:

Gallbladder Proteome RNA-sequencing Systems biology Transcriptome

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Area of Science:

Molecular Biology
Proteomics
Genomics

Background:

Understanding human gallbladder physiology requires comprehensive protein analysis.
Identifying tissue-specific proteins is key to discovering molecular regulators.

Purpose of the Study:

To identify and characterize gallbladder-specific proteins.
To explore the biological and metabolic functions of these proteins.

Main Methods:

Genome-wide deep RNA sequencing across 28 human tissues.
Antibody-based immunohistochemistry in 48 human tissues.
Cell-type and subcellular protein localization profiling.

Main Results:

140 gallbladder-specific proteins identified with elevated expression.
Genes categorized as enriched, group enriched, and enhanced based on expression levels.
Exploration of protein localization and functional roles using GO, KEGG Pathway, and HMR2.0.

Conclusions:

The study provides a comprehensive proteomic and transcriptomic profile of human gallbladder.
Identified proteins offer insights into gallbladder-specific biological processes and metabolic functions.