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Updated: Apr 25, 2026

Automated System for Single Molecule Fluorescence Measurements of Surface-immobilized Biomolecules
Published on: November 2, 2009
Stability enhancement of fluorophores for lighting up practical application in bioimaging
1Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. whzhu@ecust.edu.cn.
Abstract:
The practical application of organic fluorophores in bioimaging is severely limited due to their generally poor stability. In this Highlight, we emphasize several representative strategies including nanoparticle-encapsulating dyes, dye-doped nanoparticles and molecular engineering for stabilizing fluorophores, especially with a breakthrough in photostability for visualizing disease therapy, tumor and biological processes.
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