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PRAM score as predictor of pediatric asthma hospitalization
Fuad Alnaji1, Roger Zemek, Nick Barrowman
1The Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa.
Insights
The 3-hour Pediatric Respiratory Assessment Measure (PRAM) score is a strong predictor of hospitalization for pediatric asthma exacerbations. This score aids clinicians in deciding on admission or further treatment to reduce hospital stays.
Area of Science:
- Pediatric Emergency Medicine
- Respiratory Medicine
- Clinical Decision Support
Background:
- Pediatric asthma exacerbations presenting to the emergency department (ED) require accurate severity assessment for timely management.
- The Pediatric Respiratory Assessment Measure (PRAM) is used to quantify asthma severity in children.
- Intensive asthma therapy, including bronchodilators and oral steroids, is often initiated in the ED.
Purpose of the Study:
- To evaluate the association between PRAM scores and the likelihood of hospital admission in pediatric patients with moderate-to-severe asthma exacerbations receiving intensive therapy.
- To determine if PRAM scores obtained at different time points predict inpatient hospitalization.
Main Methods:
- Secondary analysis of a prospective study involving pediatric patients (2-17 years) with moderate-to-severe asthma (PRAM ≥ 4).
- Patients received nurse-initiated intensive asthma therapy (bronchodilator and oral steroids) upon triage.
- PRAM scores were recorded hourly; logistic regression and Area Under the Curve (AUC) analysis were used to predict hospitalization.
Main Results:
- A total of 297 patients were analyzed, with an 11.4% admission rate among those receiving intensive therapy.
- The 3-hour PRAM score demonstrated significantly improved prediction of admission (AUC = 0.85) compared to the triage PRAM score (p = 0.04).
Conclusions:
- The PRAM score measured 3 hours after presentation is the most effective predictor of hospitalization for pediatric asthma exacerbations.
- These findings can inform clinical decisions in the ED to optimize patient management and potentially reduce hospital admissions.
Objectives:
The objective was to determine the association between asthma severity as measured by the Pediatric Respiratory Assessment Measure (PRAM) score and the likelihood of admission for pediatric patients who present to the emergency department (ED) with moderate-to-severe asthma exacerbations and who receive intensive asthma therapy.
Methods:
This was a secondary analysis of a prospective study of triage nurse-initiated steroid therapy in pediatric asthma. Children aged 2 to 17 years inclusive, presenting with moderate-to-severe acute asthma exacerbations (defined as PRAM ≥ 4), were included. To be eligible for inclusion in the study, children must have received "intensive asthma therapy," defined as nurse-initiated initial bronchodilator and oral steroid therapy at arrival to triage. PRAM scores were measured hourly as per ED protocol. The primary outcome was inpatient hospitalization; secondary outcome was ED stay greater than 8 hours. Logistic regression models were used to predict admission based on PRAM score at triage and then hourly thereafter. The area under the receiver operating characteristic curve (AUC) was calculated for each hour.
Results:
A total of 297 patients were included in the analysis, with an admission rate of 11.4% for patients receiving intensive therapy. The 3-hour PRAM (AUC = 0.85) significantly improved prediction of admission compared to PRAM at triage (p = 0.04).
Conclusions:
The 3-hour PRAM scores best predicts the need for hospitalization. These results may be applied in clinical settings to facilitate the decision to admit or initiate more aggressive adjunctive therapy to decrease the need for hospitalization.
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