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The TAKE-IT study: aims, design, and methods.

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Improving medication adherence in young kidney transplant patients is crucial. The TAKE-IT study tested a clinic-based intervention to enhance adherence to immunosuppressive drugs in adolescents and young adults.

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Area of Science:

  • Nephrology
  • Transplantation
  • Adolescent Medicine

Background:

  • Adolescent and young adult kidney transplant recipients require effective interventions to improve immunosuppressive medication adherence.
  • The Teen Adherence in Kidney transplant, Effectiveness of Intervention Trial (TAKE-IT) study addresses this critical need.

Purpose of the Study:

  • To determine the effectiveness of a clinic-based intervention in improving immunosuppressive medication adherence.
  • To evaluate educational, organizational, and behavioral components targeting common adherence barriers.

Main Methods:

  • A multicenter, prospective, open-label, parallel-arm randomized controlled trial.
  • Inclusion of participants aged 11-24 years, at least 3 months post-kidney transplant.
  • Monitoring adherence via electronic multi-dose pillboxes over a 12-month intervention period.

Main Results:

  • Recruitment initiated in Feb. 2012, with 130 participants completing baseline visits by March 31, 2014.
  • 125 participants were randomized, with varying completion rates for follow-up visits up to 15 months.

Conclusions:

  • The TAKE-IT study is evaluating a novel intervention for medication adherence in a vulnerable transplant population.
  • Ongoing data collection will inform the effectiveness of the intervention in improving adherence and patient outcomes.