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Hesperidin potentiates ghrelin signaling
Hajime Suzuki, Akihiro Asakawa, Namiko Kawamura
1Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.. asakawa@m2.kufm.kagoshima-u.ac.jp.
Recent Patents on Food, Nutrition & Agriculture
|September 2, 2014
Summary
Hesperidin, a citrus fruit compound, influences ghrelin secretion, impacting appetite and gut motility. This review explores its orexigenic and prokinetic effects, highlighting potential therapeutic applications for various diseases.
Area of Science:
- Biochemistry
- Pharmacology
- Nutritional Science
Background:
- Hesperidin is a flavanone glycoside found in citrus fruits.
- It exhibits diverse biological activities, including anti-cancer, antimicrobial, and antiviral effects.
- Previous research suggests hesperidin influences ghrelin secretion via serotonin receptor antagonism.
Purpose of the Study:
- To review studies on the orexigenic and prokinetic activities of hesperidin.
- To explore the role of hesperidin in ghrelin secretion.
- To present relevant patents concerning hesperidin.
Main Methods:
- Literature review of existing studies on hesperidin.
- Analysis of research on hesperidin's effects on ghrelin secretion.
- Examination of patents related to hesperidin applications.
Main Results:
- Hesperidin demonstrates potential orexigenic (appetite-stimulating) and prokinetic (gut motility-enhancing) properties.
- Its mechanism may involve the modulation of ghrelin secretion.
- Several patents highlight hesperidin's therapeutic potential.
Conclusions:
- Hesperidin shows promise as a therapeutic agent for conditions involving appetite regulation and gastrointestinal motility.
- Further research into hesperidin's role in ghrelin pathways is warranted.
- Its natural origin and diverse bioactivities make it an attractive compound for drug development.
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