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Published on: September 27, 2024
[Glucocorticoid and Bone. Collagen cross-link abnormalities in glucocorticoid induced osteoporosis]
1Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
Abstract:
Bone fragility is one of the side effects of glucocorticoid (GC) use, even at low doses. An increase in fracture risk due to GC administration occurs immediately after beginning treatment. A number of GC-mediated effects are responsible for bone fragility. We demonstrated that GC administration deteriorates lysyl oxidase mediated collagen crosslink formation acting as a determinant of bone material properties (Saito M, et al., Calcified Tissue Int, 88 ; 314-424, 2011) . We reviewed the mechanism of low bone material quality by GC administration.
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