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Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

22
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
22

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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Resistance training with instability in multiple system atrophy: a case report.

Carla Silva-Batista1, Hélcio Kanegusuku1, Hamilton Roschel1

  • 1School of Physical Education and Sport; University of São Paulo , São Paulo, Brazil.

Journal of Sports Science & Medicine
|September 2, 2014
PubMed
Summary

Resistance training with instability improved quality of life, motor function, and neuromuscular parameters in a Multiple System Atrophy (MSA) patient. This non-pharmacological approach showed significant benefits, including reduced fall risk and improved daily activities.

Keywords:
Exercise trainingcross-sectional areamotor symptomsrisk of falls

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Area of Science:

  • Neurology
  • Exercise Physiology
  • Rehabilitation Science

Background:

  • Multiple System Atrophy (MSA) is a progressive neurodegenerative disorder impacting motor control and quality of life.
  • Current treatments for MSA are primarily pharmacological and offer limited symptomatic relief.
  • Non-pharmacological interventions like exercise are being explored for their potential therapeutic benefits in MSA.

Purpose of the Study:

  • To assess the effects of a six-month resistance training program with instability devices on a patient with Multiple System Atrophy (MSA).
  • To evaluate changes in quality of life, activities of daily living, motor symptoms, functional ability, and neuromuscular parameters.
  • To investigate the impact on mRNA expression of genes related to muscle protein synthesis and degradation.

Main Methods:

  • A single-patient case report involving a patient diagnosed with MSA.
  • Implementation of a structured resistance training program using instability devices (e.g., Bosu ball, Swiss ball) twice weekly for six months.
  • Assessment of various clinical outcomes including muscle strength (leg press 1RM), muscle cross-sectional area, functional tests (Timed Up and Go, Sit to Stand), balance, quality of life questionnaires, and gene expression analysis.

Main Results:

  • Significant improvements were observed in quadriceps muscle size (+6.4-6.8%) and leg press strength (+40%).
  • Functional outcomes showed marked improvements: Timed Up and Go (-33.3%), Sit to Stand (-28.6%), dynamic balance (+42.3%), and Activities of Daily Living (+40.1%).
  • Motor symptom severity decreased by 32%, fall risk reduced by 128.1%, and quality of life subscales improved significantly (13.0-100.0%).
  • mRNA expression of mechanogrowth factor and mammalian target of rapamycin increased by 12.7-fold and 1.5-fold, respectively.

Conclusions:

  • This case report suggests that resistance training with instability may serve as a beneficial non-pharmacological intervention for individuals with MSA.
  • The intervention demonstrated potential to alleviate MSA-related motor deficits, enhance functional capacity, and improve overall quality of life.
  • Further research with larger sample sizes is warranted to confirm these findings and establish causality, as this study's results cannot be generalized to the entire MSA population.