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Updated: Apr 24, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes
Shuo-Bin Chen1, Wei-Bin Wu, Ming-Hao Hu
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tanjiah@mail.sysu.edu.cn ceshzs@mail.sysu.edu.cn.
Abstract:
A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.
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