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Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324
Lidiya A Maslovskaya1, Andrei I Savchenko, Elizabeth H Krenske
1QIMR Berghofer Medical Research Institute, PO Royal Brisbane Hospital, Brisbane, 4029, Queensland, Australia.
Abstract:
Investigation of Croton insularis afforded the first in class seco-casbane diterpene, EBC-329. A highly oxidised casbane, EBC-324, was also isolated. The structural motif within EBC-324, which consists of an epoxidised hemi-acetal endoperoxide, is new to the casbane family.
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