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Updated: Apr 24, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Laryngeal histoplasmosis.

M K Masud¹, S M Ahmad, F Ferdouse

¹Dr Mostafa Kamal Masud, Registrar (ENT), Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

Mymensingh Medical Journal : MMJ

|September 3, 2014

Summary

This summary is machine-generated.

Histoplasmosis, a fungal infection, rarely affects the larynx in immunocompetent individuals. This case highlights its potential to mimic tuberculosis or cancer, emphasizing the need for accurate diagnosis.

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Area of Science:

Mycology
Infectious Diseases
Otolaryngology

Background:

Histoplasma capsulatum is an endemic fungus causing granulomatous disease.
Laryngeal involvement is an uncommon manifestation, particularly in immunocompetent patients.

Observation:

A 60-year-old farmer presented with voice changes and cough, initially suspected as laryngeal tuberculosis or neoplasm.
Laryngoscopy revealed vocal cord edema, erythema, and leukoplakia.
Histopathology confirmed intracellular Histoplasma capsulatum hyphae.

Findings:

The patient was diagnosed with laryngeal histoplasmosis.
Treatment led to patient improvement.

Implications:

Laryngeal histoplasmosis can mimic laryngeal tuberculosis and squamous cell carcinoma.
Accurate diagnosis requires a high index of suspicion and thorough histological examination.
Misdiagnosis can lead to inappropriate treatment for tuberculosis or laryngeal cancer.