Surface decorated poly(ester-ether-urethane)s nanoparticles: a versatile approach towards clinical translation.

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Nanotechnology

Background:

• Poly(ester-ether-urethane)s are versatile biopolymers for nanocarrier development.
• Clinical translation of these synthetic materials requires further development for biological and quality aspects.

Purpose of the Study:

• To synthesize poly(ε-caprolactone)-co-poly(ethylene glycol) copolymers for drug delivery.
• To develop paclitaxel-loaded nanoparticles with functionalized surfaces.

Main Methods:

• Semi-bulk pilot scale synthesis of copolymers under mild, catalyst-free conditions.
• Functionalization of copolymer termini with fluorescein tags and anticancer moieties.
• Processing of copolymers into paclitaxel-loaded nanoparticles (NPs) and comprehensive characterization.

Main Results:

• Successful synthesis of functionalized poly(ester-ether-urethane)s copolymers.
• Development of paclitaxel-loaded nanoparticles with enhanced characteristics.
• In vitro and in vivo studies demonstrated no observed toxicity in healthy mice.
• Lower paclitaxel accumulation in the lungs and spleen compared to conventional dosage forms.

Conclusions:

• Synthesized poly(ester-ether-urethane)s copolymers are suitable for creating safe and effective nanocarriers.
• Paclitaxel-loaded nanoparticles show potential for improved drug delivery with reduced systemic toxicity.
• This approach facilitates the clinical translation of advanced biopolymer-based drug delivery systems.