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Updated: Jul 21, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Rectal effluent as a research tool.

Jana M Rocker¹, Jack A DiPalma, Lewis K Pannell

¹University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA, jrocker@health.southalabama.edu.

Digestive Diseases and Sciences

|September 3, 2014

Summary

Gastrointestinal (GI) lavage fluid, collected noninvasively via rectal effluent, offers a rich resource for research. This review explores its applications and methods for collection and analysis.

Area of Science:

Gastroenterology
Clinical Research
Biomarker Discovery

Background:

Localized secretions offer superior molecular insights compared to blood.
Lavage techniques efficiently collect cells and soluble factors from body cavities.
Gastrointestinal (GI) lavage fluid, particularly rectal effluent, is an abundant, underutilized research resource.

Purpose of the Study:

To review the applications of rectal effluent as a research tool.
To consolidate information on methods for collecting, stabilizing, and analyzing GI lavage fluid.
To address the challenge of locating studies due to varied terminology for rectal effluent.

Main Methods:

Review of existing literature on rectal effluent applications in research.
Discussion of methods for noninvasive collection of GI lavage fluid (e.g., via toilet receptacle).

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Exploration of techniques for sample stabilization and analysis.

Main Results:

Rectal effluent has been successfully used to study various GI conditions, including diarrheal disease, inflammatory bowel disease, celiac disease, and cancer.
Noninvasive collection methods are feasible and yield significant research material.
Standardized terminology and comprehensive reviews are lacking, hindering literature discovery.

Conclusions:

GI lavage fluid represents a valuable, largely untapped resource for basic and clinical research.
Standardized collection and analysis methods are needed to maximize its potential.
Further research and reviews are essential to establish rectal effluent as a mainstream research tool.