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Published on: August 28, 2018
MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2
Shujun Feng1, Wenjing Pan, Ye Jin
1Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, 150001, Harbin, China.
Abstract:
Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.
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