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Mean platelet volume is not associated with coronary slow flow: a retrospective cohort study
Zekeriya Kaya1, Özgür Günebakmaz, Ali Yıldız
1Department of Cardiology, Faculty of Medicine, Harran University; Şanlıurfa-Turkey. drgunebakmaz@yahoo.com.
Insights
Mean platelet volume (MPV) is not a predictor of coronary slow flow (CSF). Height and serum uric acid levels are independent predictors of CSF and coronary blood flow, impacting patients with stable angina pectoris.
Area of Science:
- Cardiology
- Vascular Biology
Background:
- Coronary slow flow (CSF) is a condition affecting coronary blood flow.
- Mean platelet volume (MPV) is a marker of platelet activation and size.
- The relationship between MPV and CSF requires further investigation.
Purpose of the Study:
- To determine if mean platelet volume (MPV) levels differ in patients with coronary slow flow (CSF).
- To identify predictors of CSF and coronary blood flow.
Main Methods:
- A retrospective cohort study included 465 patients with stable angina pectoris.
- Patients were categorized into CSF (n=76) and control (n=389) groups.
- Coronary blood flow was assessed using TIMI frame count (TFC); MPV and other variables were recorded.
Main Results:
- MPV levels did not significantly differ between CSF and control groups.
- Height and serum uric acid levels were identified as independent predictors of CSF.
- Height and serum uric acid levels were also independent predictors of mean TFC.
Conclusions:
- MPV is not an independent predictor of coronary slow flow (CSF).
- Height and serum uric acid levels are significant independent predictors of both CSF and coronary blood flow (mean TFC).
- These findings suggest specific clinical factors associated with impaired coronary flow.
Objective:
To investigate mean platelet volume (MPV) levels in patients with coronary slow flow (CSF).
Methods:
465 stable angina pectoris cases with angiographically normal coronary arteries were recruited [coronary slow flow group (n=76), control group (n=389)] in the observational retrospective cohort study. Clinical, biochemical and demographic variables including MPV were noted and coronary blood flow was assessed with TIMI frame count (TFC).
Results:
Gender, smoking, height, serum creatinine, uric acid levels, hemoglobin, waist/hip ratio, systolic blood pressure but not MPV were significantly different among groups. Independent predictors of CSF were height (p=.029) and serum uric acid level (p=.045). Gender, height, weight, hip circumference, systolic blood pressure, fasting blood glucose, serum urea, creatinine, uric acid levels, hemoglobin and platelet count were associated with mean TFC whereas independent predictors of mean TIMI frame count were height (p=.010) and serum uric acid level (p=.041).
Conclusion:
Height and serum uric acid level but not MPV were independent predictors of both CSF and mean TFC.
