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Influence of the left ventricular types on QT intervals in hypertensive patients
Juraj Kunisek1, Luka Zaputovic, Zlatko Cubranic
1Thalassotherapia Crikvenica, Special Hospital for Medical Rehabilitation; Crikvenica-Croatia. juraj_kunisek@net.hr.
Insights
This study found no significant link between left ventricular hypertrophy types and QT intervals or dispersion. However, QT intervals and dispersion showed a tendency to increase with left ventricular mass in concentric and eccentric hypertrophy.
Area of Science:
- Cardiology
- Electrophysiology
- Hypertension Research
Background:
- Left ventricular hypertrophy (LVH) presents in concentric, eccentric, and asymmetric types.
- Understanding the electrophysiological differences between LVH types is crucial for managing associated risks.
Purpose of the Study:
- To investigate the electrophysiological underpinnings of varying excitability in different left ventricular hypertrophy types.
- To compare electrophysiological parameters across concentric, eccentric, and asymmetric LVH.
Main Methods:
- 187 hypertensive patients without ischemic heart disease were classified by LVH type (concentric, eccentric, asymmetric) and severity (mild, moderate, severe).
- Measurements included QT intervals, QT dispersion, left ventricular mass index, and ventricular arrhythmias.
- Standard upper limits for QT corrected interval (450/460 ms) and QT dispersion (70 ms) were used.
Main Results:
- Severe concentric and eccentric LVH showed increased QT corrected interval and QT dispersion, though not significantly.
- QT dispersion was significantly higher in men with severe LVH (67.5 vs. 30 ms, p=0.047).
- Patients with complex ventricular arrhythmias had significantly longer QT intervals (p=0.037).
Conclusions:
- No significant association was found between QT intervals/dispersion and the degree or type of LVH.
- A trend for increased QT corrected interval and QT dispersion with LVH mass was observed specifically in concentric and eccentric types.
Objective:
To investigate the possible electrophysiological background of the greater excitability of concentric and eccentric left ventricular hypertrophy types in relation to the asymmetric type.
Methods:
187 patients with essential hypertension, without ishaemic heart disease were divided into three groups with regard to left ventricule type: concentric (relative wall thickness >0.42, interventricular septum/left ventricular posterior wall ≤1.3), eccentric (left ventricular diameter in systoles >32, relative wall thickness <0.42), asymmetric left ventricular hypertrophy (interventricular septum/left ventricular posterior wall >1.3), and three subgroups: mild (interventricular septum or left ventricular posterior wall 11-12 mm), moderate (interventricular septum or left ventricular posterior wall 13-14 mm) and severe left ventricular hypertrophy (interventricular septum or left ventricular posterior wall ≥15 mm). In all patients QT intervals, QT dispersion, left ventricular mass index and ventricular arrhythmias were measured. An upper normal limit for QT corrected interval: 450/460 ms for men/women; for QT dispersion: 70 ms.
Results:
The QT corrected interval and QT dispersion were increased in severe concentric and eccentric left ventricular hypertrophy (443 and 480 ms for QT corrected; 53 and 45 ms for QT dispersion, respectively), not significantly. QT dispersion in men with severe left ventricular hypertrophy was significantly enlarged (67.5 vs. 30 ms, p=0.047). QT interval was significantly longer in patients with complex ventricular arrhythmias (p=0.037).
Conclusion:
No significant association of QT intervals or QT dispersion with the degree/type of left ventricular hypertrophy was found. QT corrected interval and QT dispersion tend to increase proportionally to the left ventricular mass only in the concentric and eccentric type.
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