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A Porcine Model of Acute Autologous Pulmonary Embolism

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

Concurrent pulmonary thrombosis with systemic embolism: a case report.

Xiao-jie Xie¹, Ju-bo Jiang, Jun Jiang

¹Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Journal of Zhejiang University. Science. B

|September 4, 2014

Summary

Combined anticoagulation and antiplatelet therapy is effective for arteriovenous embolism. This treatment approach improved prognosis in a patient with coexisting venous thromboembolism and arterial thrombosis, without major bleeding.

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Area of Science:

Cardiology
Hematology
Vascular Medicine

Background:

Arteriovenous embolism, a rare condition involving both venous thromboembolism and arterial thrombosis, presents significant clinical challenges.
Simultaneous occurrence of venous and arterial thrombosis necessitates careful management to balance ischemic and hemorrhagic risks.

Observation:

A 55-year-old female presented with acute pulmonary embolism (PE), acute myocardial infarction (AMI), and cerebral infarction.
Initial investigations excluded common hypercoagulable states, arteriovenous shunts, and malignancy.
The patient was treated with rivaroxaban (Xa inhibitor) and clopidogrel (ADP receptor inhibitor), along with a beta-blocker and atorvastatin.

Findings:

The combined therapy led to initial embolus shrinkage over 10 months, followed by re-expansion.

Keywords:

Acute myocardial infarction (AMI)Cerebral infarction Pulmonary thrombosis Ventricular aneurysm

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An aneurysm of the left ventricular apex was detected via echocardiogram during follow-up.

An angiotensin-converting enzyme inhibitor was added to the treatment regimen.

Implications:

Combined anticoagulation and antiplatelet therapy can effectively manage complex arteriovenous embolism cases.
This therapeutic strategy demonstrated significant symptom relief and improved prognosis in the reported patient.
The findings support the use of dual therapy in select patients with arteriovenous embolism, emphasizing the need for vigilant monitoring for complications such as aneurysms.