Related Experiment Video

Updated: Apr 24, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

551

New targets and new mechanisms in lung cancer

Daniel R Carrizosa1, Kathryn F Mileham, Daniel E Haggstrom

  • 1Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, USA.

Oncology (Williston Park, N.Y.)
|September 4, 2014
PubMed

Insights

Histology is key in non-small-cell lung cancer (NSCLC) therapy. This review covers targeted agents, immunotherapy, and chemotherapy advancements for NSCLC treatment.

Area of Science:

  • Oncology
  • Pulmonology
  • Pharmacology

Background:

  • Histology is increasingly vital in non-small-cell lung cancer (NSCLC) diagnosis.
  • Emerging targeted therapies are revolutionizing NSCLC treatment paradigms.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for NSCLC.
  • To discuss advancements in targeted agents, immunotherapy, and chemotherapy.

Main Methods:

  • Literature review of recent studies and clinical trials.
  • Synthesis of information on various therapeutic modalities.

Main Results:

  • Vascular endothelial growth factor (VEGF) antibodies are established treatments.
  • Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibitors are widely used.
  • New agents target intracellular pathways like MET and fibroblast growth factor receptor (FGFR).
  • Immunotherapy and novel chemotherapy regimens show promise.

Conclusions:

  • NSCLC treatment is rapidly evolving with targeted therapies and immunotherapy.
  • A comprehensive understanding of these agents is crucial for effective patient management.

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