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Updated: Apr 24, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery
Meihua Yu1, Yuting Niu, Yannan Yang
1Australian Institute for Bioengineering and Nanotechnology and ‡School of Biomedical Sciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Abstract:
A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of ∼10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.
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