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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Harmonic Nanoparticles for Regenerative Research
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Hollow micro-/nanostructures for enhanced pathogen theranostics.

Liang Zhang1, Yuechun Li2, Yuanyuan Zhao1

  • 1State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University (NPU), Xi'an 710072, China. lizhi.liu@nwpu.edu.cn.

Chemical Society Reviews
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Hollow micro-/nanostructures offer novel solutions for antimicrobial resistance, enhancing bacterial biosensing and therapy. These structures provide advanced pathogen diagnostics and treatments for a post-antibiotic era.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Antimicrobial resistance (AMR) poses a critical global health threat, necessitating innovative approaches to combat pathogenic infections.
  • Traditional treatments are becoming less effective, driving the need for new diagnostic and therapeutic strategies.

Purpose of the Study:

  • To comprehensively review recent advancements in hollow micro-/nanostructures for pathogen theranostics.
  • To explore their applications in bacterial biosensing and antibacterial therapy.
  • To analyze challenges and propose future directions for clinical translation.

Main Methods:

  • Systematic review of literature on hollow micro-/nanostructures synthesis, engineering, and functional mechanisms.
  • Analysis of diverse sensing modalities (colorimetric, fluorescence, SERS, electrochemical, photothermal) for bacterial detection.
  • Evaluation of antibacterial mechanisms including enzyme-mimetic catalysis, photothermal/photocatalytic activity, drug release, and piezocatalysis.

Main Results:

  • Hollow micro-/nanostructures significantly enhance analytical performance in bacterial biosensing, enabling rapid and accurate diagnostics.
  • Their unique properties facilitate versatile and efficient antibacterial therapies.
  • Review highlights diverse synthetic routes and structural designs tailored for specific theranostic functions.

Conclusions:

  • Hollow micro-/nanostructures represent a disruptive platform for next-generation pathogen management.
  • Addressing challenges in scalability, biocompatibility, and clinical translation is crucial for realizing their full potential.
  • Interdisciplinary collaboration is key to advancing this field and safeguarding global health in the post-antibiotic era.