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Updated: Apr 24, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis of (±)-terpendole E
Takaaki Teranishi1, Tetsuro Murokawa, Masaru Enomoto
1a Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
Abstract:
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.
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