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Tracing the roots of cancer evolution

Yanwen Jiang1, Olivier Elemento2

  • 1Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York.

Cancer Discovery
|September 4, 2014
PubMed
Summary

Chronic lymphocytic leukemia (CLL) originates from preleukemic progenitor cells, with early mutations identified. B-cell receptor signaling deregulation is a key hallmark, especially with EGR2 mutations.

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