Related Experiment Video

Updated: Apr 24, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

5.5K

Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation

Oliver Andres1, Harald Schulze, Christian P Speer

  • 1Dr. med. Oliver Andres, University Children's Hospital Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany, Tel.: +49 931 201 27728, Fax: +49 931 201 6027799,

Thrombosis and Haemostasis
|September 5, 2014
PubMed

Insights

Neonatal platelets differ significantly from adult platelets and may impact infant sepsis and intraventricular hemorrhage. Further research is crucial for understanding neonatal platelet function in critical care.

Area of Science:

  • Neonatal immunology
  • Hematology
  • Pediatric critical care

Background:

  • Platelets are crucial for hemostasis, antimicrobial defense, and inflammation.
  • Limited data exists on neonatal platelet physiology due to ethical restrictions.
  • Understanding neonatal platelets is vital for critically ill infants.

Purpose of the Study:

  • To summarize current knowledge on neonatal platelet count, morphology, and function.
  • To provide insights into advances in neonatal platelet immunology.
  • To bridge the knowledge gap for neonatologists and platelet researchers.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of neonatal platelet count and morphology.
  • Review of studies on neonatal platelet function in primary hemostasis.
  • Exploration of recent findings in platelet immunology.

Main Results:

  • Neonatal platelets originate from liver megakaryocytes and differ from adult platelets.
  • Platelet count and morphology in neonates show distinct characteristics.
  • Neonatal platelet immunology has significant clinical implications.

Conclusions:

  • Neonatal platelets possess unique properties compared to adult platelets.
  • These distinct platelet characteristics may play a role in neonatal sepsis and intraventricular hemorrhage.
  • Further investigation into neonatal platelet roles is essential for improving perinatal outcomes.

Keywords:
Platelet functionintraventricular haemorrhageneonatal sepsisplatelet immunologypreterm infant

More Related Videos

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

15.0K
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

3.5K

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
6.8K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.1K
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
13.7K
Inflammation01:38

Inflammation

Overview
46.1K
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect...
64
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
45