Less is more: structures of difficult targets with minimal constraints
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Updated: Apr 24, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Neil R Lloyd1, Deborah S Wuttke1
1Department of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309, USA.
Abstract:
By merging recent experimental and computational methodology advances, resolution-adapted structural recombination Rosetta has emerged as a powerful strategy for solving the structure of traditionally challenging targets. In this issue of Structure, Sgourakis and colleagues solve the structure of one such target, the immunoevasin protein m04, using this approach.
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