Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catenins01:23

Catenins

2.2K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.2K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

6.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
6.4K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.5K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary coexistence of immunoglobulin light chain amyloidosis and light chain deposition disease: A case report.

Respiratory medicine case reports·2026
Same author

Nintedanib inhibits the VEGFR-ERK signaling pathway in human KRAS-mutated cancer cells.

Cell death & disease·2026
Same author

User Engagement and Demographics of a Medical Society-Led Website for Scoliosis: An Analysis using Google Analytics.

Spine surgery and related research·2026
Same author

A Case Report of an Intradural Extramedullary Tumor, Which Was Treated With Steroid and Clinically Suspected as Neural Sarcoidosis.

Case reports in orthopedics·2026
Same author

Reply to Letter to the Editor Regarding the Article: "Prediction of hip Development Using Femoral Head Cartilage and Acetabular Cartilage Diameters on MRI Images".

Journal of pediatric orthopedics·2026
Same author

Editorial: Advances in limb-salvage surgery and reconstruction for pediatric bone and soft tissue tumors.

Frontiers in pediatrics·2026

Related Experiment Video

Updated: Apr 24, 2026

Transplantation Into the Mouse Ovarian Fat Pad
09:25

Transplantation Into the Mouse Ovarian Fat Pad

Published on: September 7, 2016

11.5K

β-catenin mutation in ovarian solid pseudopapillary neoplasm.

Ayami Kominami1, Masahiko Fujino, Hideki Murakami

  • 1Department of Pathology, Japanese Red Cross, Nagoya 1st Hospital, Nagoya, Japan.

Pathology International
|September 5, 2014
PubMed
Summary

Solid pseudopapillary neoplasm (SPN) of the ovary is rare. This study found ovarian SPN shares histological and genetic similarities with pancreatic SPN, suggesting a common Wnt/β-catenin pathway in tumorigenesis.

Keywords:
ovarysolid pseudopapillary neoplasmβ-catenin

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.3K
Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

10.9K

Related Experiment Videos

Last Updated: Apr 24, 2026

Transplantation Into the Mouse Ovarian Fat Pad
09:25

Transplantation Into the Mouse Ovarian Fat Pad

Published on: September 7, 2016

11.5K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.3K
Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

10.9K

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Solid pseudopapillary neoplasm (SPN) of the ovary is an exceptionally rare tumor with an unclear pathogenesis.
  • Only a few cases have been documented, highlighting the need for further research into its origins.

Observation:

  • A case of primary ovarian SPN in an 18-year-old female is presented.
  • Histological examination revealed predominantly solid patterns with focal pseudopapillary features.
  • Immunohistochemistry showed positivity for β-catenin, α1-antitrypsin, vimentin, CD56, and CD10.

Findings:

  • Genetic analysis identified a specific point mutation (c.110C >T) in the β-catenin gene (CTNNB1), leading to a Ser37 mutation.
  • This mutation is recognized as a key oncogenic driver in pancreatic SPN.
  • Ovarian SPN exhibited similar histological features and genetic characteristics to pancreatic SPN.

Implications:

  • The findings suggest that ovarian and pancreatic SPNs may share a common oncogenesis pathway.
  • The Wnt/β-catenin pathway is implicated in the tumorgenesis of both ovarian and pancreatic SPNs.
  • This research provides valuable insights into the molecular basis of ovarian SPN, aiding in differential diagnosis and potential therapeutic strategies.