Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

416
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
416
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

7.5K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.5K
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

553
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
553
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

846
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
846
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

874
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
874
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

3.4K
IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Economic Stability of Children, a Key Social Determinant of Health, in the United States: Differences by Rurality.

The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association·2026
Same author

A pipeline to characterize spinal cord pathology in neurological disorders combining magnetic resonance microscopy and histopathology.

Communications medicine·2026
Same author

High-Field Multinuclear MRI Reveals Sodium Relaxation Heterogeneity in Cortical Organoids.

bioRxiv : the preprint server for biology·2026
Same author

Electro-Calcium uncoupling precedes neurodegeneration in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

Pharmacological Interventions in Autism Spectrum Disorder: A Comprehensive Review of Mechanisms and Efficacy.

Biomedicines·2025
Same author

Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.

Science advances·2025
Same journal

Blood Pressure Responses to Dietary Salt in Renin-Deficient Dahl Salt-Sensitive Rats.

American journal of physiology. Renal physiology·2026
Same journal

Cytokine Profiles in Patients with Chronic Kidney Disease and Low Sexual Function.

American journal of physiology. Renal physiology·2026
Same journal

Renovascular disease induces functionally relevant, locus-specific alterations to DNA methylation and hydroxymethylation in swine scattered tubular-like cells.

American journal of physiology. Renal physiology·2026
Same journal

Nitrite Protects Against Cardiac Surgery-Associated Acute Kidney Injury via Inflammation Suppression: Insights from a Rat Cardiopulmonary Bypass Model.

American journal of physiology. Renal physiology·2026
Same journal

Etanercept attenuates TNFα-mediated kidney injury in a rat model of brain death kidney donation.

American journal of physiology. Renal physiology·2026
Same journal

Phosphorylation of aquaporin-2 at serine 269 in urinary extracellular vesicles reflects renal vasopressin activity in rats.

American journal of physiology. Renal physiology·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice
06:58

Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice

Published on: February 27, 2026

169

Live nephron imaging by MRI.

Chunqi Qian1, Xin Yu2, Nikorn Pothayee3

  • 1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland; qianc2@ninds.nih.gov.

American Journal of Physiology. Renal Physiology
|September 5, 2014
PubMed
Summary
This summary is machine-generated.

New wireless magnetic resonance imaging (MRI) detectors enhance local sensitivity for improved kidney imaging. This technology enables real-time visualization of renal structures and function without invasive cables.

Keywords:
MRIfiltrationglomeruliperfusionrenal tubules

More Related Videos

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

10.9K
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

12.3K

Related Experiment Videos

Last Updated: Apr 24, 2026

Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice
06:58

Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice

Published on: February 27, 2026

169
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

10.9K
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

12.3K

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Nephrology

Background:

  • Improving local sensitivity in Magnetic Resonance Imaging (MRI) is crucial for detailed anatomical and functional studies.
  • Traditional MRI setups with local detectors require cable connections, limiting their application in sensitive areas and implantable devices.
  • Recent advancements include integrated wireless amplifiers that enhance signal detection without cables, enabling new imaging possibilities.

Purpose of the Study:

  • To evaluate the utility of a novel integrated wireless MRI detector system for enhanced renal imaging.
  • To demonstrate the capability of this system for visualizing kidney structures, including glomeruli and tubules, with and without contrast agents.
  • To explore the potential of this technology for in vivo observation of nephron function.

Main Methods:

  • Utilized an integrated wireless MRI detector system for high-resolution kidney imaging.
  • Developed methods for imaging glomeruli based on natural hyperintensity due to high blood flow.
  • Employed Manganese (Mn(2+)) as a contrast agent for simultaneous visualization and differentiation of glomeruli and renal tubules based on T1-weighted MRI enhancement and absorption dynamics.

Main Results:

  • Successfully imaged individual glomeruli as hyperintense regions without contrast agents by detecting high blood flow.
  • Achieved simultaneous detection of glomeruli and renal tubules using Mn(2+), with tubules showing differential enhancement due to selective reabsorption.
  • Dynamic Mn(2+) absorption studies confirmed distinct affinities of glomeruli and tubules, indicating potential for functional assessment.

Conclusions:

  • The integrated wireless MRI detector system significantly enhances local sensitivity, enabling detailed, cable-free imaging of renal structures.
  • This technology allows for real-time, non-invasive visualization of kidney glomeruli and tubules, offering new diagnostic and research avenues.
  • The ability to dynamically assess Mn(2+) absorption suggests potential for in vivo monitoring of nephron function and disease.