Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.4K
Healing II: Complications01:24

Healing II: Complications

30
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
30
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

2.7K
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
2.7K
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

1.3K
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
1.3K
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

2.8K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.8K
Vascular Spasm01:16

Vascular Spasm

4.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphene oxide functionalized with polyamidoamine dendrimer as a drug delivery system for human breast cells.

Biomaterials advances·2026
Same author

Exploring Key Regulators of Mitochondrial Dynamics and Immune Response in SARS-CoV-2 Infection.

Viruses·2026
Same author

Layers of Hope: How Graphene and Nanostructures Hold Promise for Cancer Therapy.

International journal of molecular sciences·2026
Same author

Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind Clinical and In Vitro Study.

Journal of cosmetic dermatology·2026
Same author

Hormesis and cancer therapy.

Progress in brain research·2025
Same author

Treatment of the Temples: Brazilian Consensus.

Aesthetic plastic surgery·2024

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

2.1K

Topical verapamil as a scar modulator.

Ricardo Frota Boggio1, Leonardo Frota Boggio, Bruno Luiz Galvão

  • 1Department of Cell and Development Biology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1524, ICB I rooms 306/307, Butantan, São Paulo, SP, 05508-900, Brazil, ricardoboggio@ricardoboggio.com.br.

Aesthetic Plastic Surgery
|September 6, 2014
PubMed
Summary

Topical verapamil significantly improves scar quality after plastic surgery. This scar modulator demonstrated a high success rate in reducing pathological scarring, with no adverse effects reported.

More Related Videos

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

2.5K
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

6.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

2.1K
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

2.5K
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

6.4K

Area of Science:

  • Plastic Surgery
  • Dermatology
  • Wound Healing Research

Background:

  • Skin injuries initiate complex healing processes.
  • Failures in wound healing can lead to pathological scarring.
  • Scar modulation is crucial in reconstructive and aesthetic surgery.

Purpose of the Study:

  • To assess the efficacy of topical verapamil as a scar modulator.
  • To evaluate its impact on scar quality post-abdominoplasty and mammoplasty.

Main Methods:

  • A clinical trial involving 120 patients (60 abdominoplasty, 60 mammoplasty).
  • Half of the patients received topical verapamil (50 µM) post-surgery.
  • Scars were evaluated by five observers using the Stony Brook Scale three months post-operation.

Main Results:

  • Topical verapamil significantly improved scar quality compared to controls (p < 0.05).
  • Good-quality scarring was achieved in 80% of mammoplasty and 75.2% of abdominoplasty scars with verapamil.
  • Control groups showed lower satisfaction rates (48% and 51.2% respectively).
  • No adverse reactions were reported with topical verapamil use.

Conclusions:

  • Topical verapamil is effective in modulating scar healing in the postoperative period.
  • It significantly reduces the incidence of keloids and hypertrophic scars.
  • Verapamil (50 µM) is a safe and effective option for scar management after plastic surgery.