Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Toll-like Receptor 4 Knockout Mice are Protected Against PMOS-like Pathogenesis.

Reproduction (Cambridge, England)·2026

Same author

Developmental trajectories of somatostatin-positive interneurons in the human auditory cortex from migration to maturation.

Communications biology·2026

Same author

Comment on "Impact of a Pharmacist Driven Penicillin Allergy De-labeling Protocol on Rates of Reported Allergy in the Intensive Care Unit".

Hospital pharmacy·2026

Same author

Electroacupuncture improves cognitive function and neuropsychiatric symptoms in breast cancer survivors: a pilot randomized controlled trial.

Journal of the National Cancer Institute·2026

Same author

Editorial: Transforming vaccine strategies: co-delivery systems for robust immunity and disease control.

Frontiers in immunology·2026

Same author

Comment on 'The Influence of Missed Nursing Care on Satisfaction With Nursing Care and Trust in Nurses Among Patients With Cancer: A Descriptive, Correlational Study'.

Journal of clinical nursing·2026

Search research articles

Related Experiment Video

Updated: Apr 24, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Alterations in gene array patterns in dendritic cells from aged humans.

Jia-ning Cao¹, Anshu Agrawal¹, Edward Sharman²

¹Division of Basic and Clinical Immunology, Department of Medicine, University of California Irvine, Irvine, California, United States of America.

|September 6, 2014

Summary

This summary is machine-generated.

Aging impairs dendritic cell (DC) function by altering gene expression. Key immune and cell cycle genes are downregulated in aged DCs, contributing to reduced immunity in older adults.

More Related Videos

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Related Experiment Videos

Last Updated: Apr 24, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Area of Science:

Immunology
Gerontology
Molecular Biology

Background:

Dendritic cells (DCs) are crucial antigen-presenting cells regulating immune responses and maintaining tolerance.
DC function declines with age, potentially impacting adaptive immunity in the elderly.
Understanding these age-related molecular changes is vital for addressing immune senescence.

Purpose of the Study:

To identify age-associated molecular alterations in human dendritic cells.
To investigate gene expression changes in monocyte-derived DCs (MoDCs) from aged versus young donors.

Main Methods:

Gene array analysis using Affymetrix GeneChips.
Comparison of gene expression profiles between MoDCs from aged and young human donors.

Main Results:

Significant differential expression of 260 genes (1.8%) in aged MoDCs compared to young MoDCs.
144 genes were downregulated and 116 were upregulated.
Genes involved in pathogen immune response, cell migration, T cell priming, cell cycle arrest, and DNA replication showed significant age-related changes, with many downregulated by over 3-fold.

Conclusions:

Age-associated changes in gene expression provide molecular evidence for functional abnormalities in human DCs.
Downregulation of genes related to cell cycle arrest and DNA replication may contribute to genetic instability in aging.
These molecular shifts in DCs likely underlie the observed defects in adaptive immunity in the elderly.