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Lymphangiomatosis with dental involvement
Mordechai Findler1, Avraham Hirshberg, Elad Sharon
11 Department of Hospital Oral Medicine, Hebrew University Hadassah , Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel .
Lymphatic Research and Biology
|September 6, 2014
Summary
Lymphangiomatosis, a rare disease, can cause aggressive bone and dental lesions. Histological findings suggest lymphangiomatosis and osteoclasts collaborate in hard tissue resorption.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Lymphangiomatosis is a rare, aggressive condition causing lymphangiomatous proliferation.
- Its etiology remains unknown, differing from Gorham-Stout Syndrome ('vanished bone disease').
Observation:
- A patient presented with tibial and dental lytic lesions.
- Autopsy revealed widespread lymphangiomatous proliferation in serous cavities.
- Histology of a dental lesion showed vascular spaces and bone/dentin resorption bays.
Findings:
- Histological analysis revealed fibroblastic proliferation and vascular spaces.
- Osteoclast-like multinucleated giant cells were present in resorption bays.
- These findings indicate lymphangiomatosis contributes to hard tissue resorption.
Implications:
- This study elucidates the mechanism of bone and dental lesion formation in lymphangiomatosis.
- Understanding this process may lead to targeted therapies for aggressive bone diseases.
- Further research into lymphangiomatosis etiology and pathogenesis is warranted.
