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Experimental uterus transplantation.

Liza Johannesson1, Anders Enskog1

  • 1Department of Gynaecology and Obstetrics (LJ), Department of Anaesthesiology and Intensive Care (AE), Sahlgrenska University Hospital, Gothenburg, Sweden.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|September 7, 2014
PubMed
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Uterus transplantation offers a new hope for women with absolute uterine factor infertility, a condition previously untreatable. This innovative procedure is now a clinical option, moving beyond life-saving applications of organ transplantation.

Area of Science:

  • Reproductive medicine
  • Transplant surgery
  • Medical ethics

Background:

  • Most infertility causes are treatable, but 4% of female infertility stems from untreatable uterine factors.
  • Current options for absolute uterine factor infertility include adoption and surrogacy.

Purpose of the Study:

  • To explore uterus transplantation as a viable treatment for absolute uterine factor infertility.
  • To discuss the ethical considerations surrounding uterus transplantation.

Main Methods:

  • Decades of research in animal models.
  • Transition to human clinical application.

Main Results:

  • Uterus transplantation has reached human clinical application.
Keywords:
femalehumaninfertilitytransplantationuterus

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  • Organ transplantation is expanding beyond life-threatening conditions.
  • Pregnancy is possible with uterus transplantation and immunosuppression.

    • Conclusions:

    • Uterus transplantation presents a potential solution for absolute uterine factor infertility.
    • The procedure involves multiple parties and raises ethical questions.