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Related Experiment Video

Updated: Jan 7, 2026

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats
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Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats

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Uterus Transplantation-Current Evaluation, Monitoring, and Emerging Diagnostics.

Andrew Jacques1, Giuliano Testa1, Massimo Mangiola2

  • 1Department of Surgery, Baylor Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, United States.

Clinical Chemistry
|December 30, 2025
PubMed
Summary

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Rituximab-based Induction in Vascularized Composite Allotransplantation: Prolonged Rejection-free Survival and the Role of Donor-specific Antibodies.

Plastic and reconstructive surgery. Global open·2026
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De Novo Isthmocele Formation Following Cesarean Delivery in Uterus Transplant Recipients.

Journal of minimally invasive gynecology·2026
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Establishing standards for controlled donation after circulatory determination of death in adults: the Bucharest international European Society for Organ Transplantation consensus.

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Current Landscape of Robotic Training During Transplant Surgery Fellowship: A Survey of 2025-2026 ASTS Fellows and Program Directors.

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Moving the needle on donation after circulatory death procedures.

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International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Uterus transplantation (UTx) requires standardized protocols and diagnostics for clinical adoption. Emerging molecular diagnostics and noninvasive monitoring show promise for improving outcomes in this evolving field.

Area of Science:

  • Reproductive Medicine
  • Transplantation Surgery
  • Immunology

Background:

  • Uterus transplantation (UTx) is moving from experimental to clinical practice for women with absolute uterine factor insufficiency.
  • Standardization of protocols and diagnostics is crucial for wider clinical adoption of UTx.

Purpose of the Study:

  • To review current evaluation, monitoring, and emerging diagnostics in UTx across all care phases.
  • To explore future directions for clinical diagnostics in UTx, drawing from solid organ transplantation.

Main Methods:

  • Comprehensive review of UTx care phases: preoperative, perioperative, posttransplant/pregnancy, and long-term follow-up.
  • Exploration of advanced diagnostics including molecular HLA matching and noninvasive monitoring.

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Main Results:

  • Detailed description of UTx care phases, including fertility, surgical, psychosocial, donor assessments, and immunosuppression management.
  • Identification of emerging diagnostics: molecular HLA matching, donor-derived cell-free DNA, and transcriptomics for rejection monitoring.

Conclusions:

  • Standardization of UTx protocols and diagnostics is essential for routine clinical practice.
  • Emerging molecular and noninvasive diagnostic tools offer potential for improved graft outcomes and patient care in UTx.