Gemcitabine-induced radiation recall myositis

Area of Science:

• Oncology
• Radiology
• Dermatology

Background:

• Radiation recall is an uncommon but recognized phenomenon.
• It involves acute inflammation in previously irradiated tissues following chemotherapy administration.
• This entity is well-documented in oncology but underreported in radiology literature.

Observation:

• A case of gemcitabine-induced radiation recall is presented.
• The patient had a history of radiotherapy for breast cancer metastasis.
• The recall manifested as myositis and dermatitis in the posterior thigh.

Findings:

• Gemcitabine triggered a radiation recall reaction.
• The reaction mimicked inflammatory myositis and dermatitis.
• Imaging findings in radiation recall can be varied and require clinical correlation.

Implications:

• Awareness of radiation recall is crucial for radiologists and oncologists.
• It should be considered in the differential diagnosis of myositis/dermatitis in patients with prior radiotherapy.
• Accurate diagnosis aids in appropriate patient management and treatment planning.