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Effect of vitamin C supplementation on serum uric acid in patients undergoing hemodialysis: a randomized controlled
Vajihe Biniaz1, Ali Tayebi, Abbas Ebadi
1Drug Applied Research Center Tabriz University of Medical Sciences, Tabriz; Division of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. parvin1351@yahoo.com.
Insights
Vitamin C supplementation significantly reduced serum uric acid levels in hemodialysis patients. This finding suggests vitamin C may help manage hyperuricemia in this population.
Area of Science:
- Nephrology
- Clinical Nutrition
Background:
- Hyperuricemia is linked to adverse outcomes in hemodialysis patients, including cardiovascular mortality and dialysis inadequacy.
- Investigating interventions to manage serum uric acid levels is crucial for improving patient prognosis.
Purpose of the Study:
- To evaluate the efficacy of vitamin C supplementation in reducing serum uric acid levels among patients undergoing hemodialysis.
Main Methods:
- A randomized placebo-controlled trial involving 172 hemodialysis patients.
- Intervention group received 250 mg of vitamin C thrice weekly for 8 weeks; control groups received placebo or no intervention.
- Serum uric acid and creatinine levels were measured at baseline and after 8 weeks.
Main Results:
- Median serum uric acid levels decreased significantly in the vitamin C group (from 6.2 to 5.8 mg/dL) compared to control groups (P = .02).
- Nearly half of the patients initially presented with hyperuricemia (uric acid > 6 mg/dL).
- Serum creatinine levels remained unchanged throughout the study.
Conclusions:
- Vitamin C supplementation demonstrated a significant negative association with serum uric acid levels in hemodialysis patients.
- Further research with larger cohorts and extended duration is warranted to confirm these findings.
Introduction:
Clinical studies of recent years have shown that hyperuricemia is associated with poor outcomes such as cardiovascular mortality and dialysis inadequacy in patients undergoing hemodialysis. Our study investigated the effect of vitamin C supplementation on serum uric acid levels in hemodialysis patients.
Materials And Methods:
This randomized placebo-controlled trial was conducted on 172 hemodialysis patients. They were randomly divided into the intervention group, to receive 250 mg of vitamin C, three times per week, for 8 weeks, and control groups 1 and 2, to receive placebo injection (saline) and no intervention, respectively. Serum levels of uric acid and creatinine were measured at the start of the study and also after 8 weeks.
Results:
The mean of serum levels of uric acid was 6.02 ± 1.08 mg/dL (reference range, 2.6 mg/dL to 6 mg/dL). Nearly, half of the patients (46.7%) had a serum level of uric acid greater than 6 mg/dL. The median baseline serum levels of uric acid were 6.2 mg/dL, 5.9 mg/dL, and 6 mg/dL in the intervention, control 1, and control 2 groups, respectively (P = .19). After 2 months, median levels reduced significantly in the vitamin C group to 5.8 mg/dL as compared to 6.4 mg/dL and 6.3 mg/dL in control groups (P = .02). The mean serum creatinine level had no significant changes during the study.
Conclusions:
Our results demonstrated the existence of a significant negative relationship between vitamin C and serum uric acid levels. Detailed investigations with larger sample sizes and longer-term use of vitamin C are recommended.
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