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Multiple sclerosis progression is not associated with birth timing in Italy.
Ausiliatrice Lucenti1, Stefania Galimberti2, Nadia Barizzone3
1MS Centre, SCDU Neurology, Head and Neck Department, AOU "Maggiore della Carità", Corso Mazzini 18, 28100 Novara, Italy; Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy.
Birth timing, including month and season of birth, did not significantly impact Multiple Sclerosis (MS) progression in Italian patients. This study found no association between when individuals were born and their disease severity over time.
Area of Science:
- Neurology
- Epidemiology
Background:
- Previous research suggests a link between month of birth and Multiple Sclerosis (MS) susceptibility.
- However, the influence of birth timing on MS disease progression remains under-investigated.
Purpose of the Study:
- To determine if season and month of birth correlate with disease progression in a large cohort of Italian MS patients.
- Investigating the relationship between birth timing and Multiple Sclerosis Severity Score.
Main Methods:
- Utilized quantile regression to analyze the impact of birth month and season.
- Assessed 1866 Italian patients diagnosed with Multiple Sclerosis.
- Examined the association with the median Multiple Sclerosis Severity Score.
Main Results:
- No significant temporal trends were identified after adjusting for multiple comparisons.
- Analysis revealed no statistically significant association between birth timing and MS progression.
Conclusions:
- Birth timing, encompassing month and season of birth, is not associated with disease progression in the Italian MS patient cohort.
- Findings suggest that birth timing does not influence the course of Multiple Sclerosis in this population.
