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Updated: Apr 24, 2026

Enrichment of Bruch's Membrane from Human Donor Eyes

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Published on: November 15, 2015

Macular diseases: epiretinal membrane.

Maiko Inoue¹, Kazuaki Kadonosono

¹Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan.

Developments in Ophthalmology

|September 9, 2014

Summary

Epiretinal membrane (ERM) surgery using microincision vitrectomy (MIVS) can improve vision. However, intact photoreceptor inner segment/outer segment (IS/OS) junctions on spectral domain optical coherence tomography (SD-OCT) are crucial for successful visual recovery after ERM removal.

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Area of Science:

Ophthalmology
Retinal Diseases
Surgical Innovation

Background:

Epiretinal membrane (ERM) is a common macular condition affecting the retina's internal limiting membrane.
Microincision vitrectomy surgery (MIVS) offers a minimally invasive approach for ERM treatment, aiming to improve vision.
Suboptimal visual outcomes persist in some patients post-ERM removal, necessitating prognostic indicators.

Purpose of the Study:

To evaluate the prognostic significance of the photoreceptor inner segment/outer segment (IS/OS) junction integrity on spectral domain optical coherence tomography (SD-OCT) for visual recovery after MIVS for ERM.
To establish guidelines for surgical timing based on SD-OCT findings.

Main Methods:

Retrospective analysis of patients undergoing MIVS for ERM.
Preoperative assessment of the IS/OS junction status using SD-OCT.
Correlation of IS/OS junction integrity with postoperative best-corrected visual acuity (BCVA) and visual recovery.

Main Results:

The integrity of the photoreceptor IS/OS junction on preoperative SD-OCT is a significant predictor of visual recovery and final BCVA after MIVS.
Patients with an intact IS/OS junction tend to achieve better visual outcomes.
Disruption of the IS/OS junction indicates a poorer prognosis for visual improvement.

Conclusions:

SD-OCT assessment of the IS/OS junction is vital for predicting visual outcomes in ERM patients undergoing MIVS.
Optimal surgical timing is recommended while the IS/OS junction remains intact to maximize visual potential.
Early surgical intervention is advised if the IS/OS junction is already disrupted to mitigate further vision loss.