Related Experiment Video
Updated: Apr 24, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography
1Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Brühler Strasse 7, 53119 Bonn (Germany). toni.kuehl@uni-bonn.de.
Abstract:
More than 20 years of research on heme as a temporary effector molecule of proteins have revealed its widespread impact on virtually all primary functions in the human organism. As our understanding of this influence is still growing, a comprehensive overview of compiled data will give fresh impetus for creativity and developing new strategies in heme-related research. From known data concerning heme-regulated proteins and their involvement in the development of diseases, we provide concise information of Fe(II/III) heme as a regulator and the availability of "regulatory heme". The latter is dependent on the balance between free and bound Fe(II/III) heme, here termed "hemeostasis". Imbalance of this system can lead to the development of diseases that were not always attributed to this small molecule. Diseases such as cancer or Alzheimer's disease highlight the reawakened interest in heme, whose function was previously believed to be completely understood.
More Related Videos
Related Concept Videos
Electron Transport Chain: Complex III and IV
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Globular and Fibrous Proteins
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Microbes and Other Elemental Cycles

