The Hepatocyte Growth Factor Receptor: Structure, Function and Pharmacological Targeting in Cancer

Fabiola Cecchi1, Daniel C Rabe1, Donald P Bottaro1

  • 1Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Summary

Hepatocyte growth factor (HGF)/Met signaling drives cancer progression and metastasis. Developing targeted inhibitors faces challenges in patient selection and biomarker development for effective cancer treatment.

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