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Updated: Apr 24, 2026
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats
1Department of Neurology, Section of Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.
Abstract:
Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.
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