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Updated: Apr 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Efficient synthesis of new fluorinated building blocks by means of hydroformylation
Lidia Fanfoni1, Lisa Diab1, Tomas Smejkal2
1Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany.
Abstract:
Hydroformylation of fluorinated alkenes is an efficient method for the preparation of fluorinated functionalized building blocks for the synthesis of biologically active target structures. In this article we summarize known hydroformylation reactions of fluorinated olefins and we add new results from our research groups. Particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.
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