Hypervalent iodine-based Trifluoromethylating agents made in Switzerland

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Nico Santschi1, Antonio Togni2

  • 1Westfälische Wilhelms-Universität Münster Organisch-Chemisches Institut Corrensstrasse 40, D-48149 Münster, Germany. santschi@uni-muenster.de.

Chimia
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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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