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Updated: Apr 24, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Three-dimensional spectral domain optical coherence tomography in vitreomacular traction
Sandeep Saxena1, Manisha1, Carsten H Meyer2
1Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Abstract:
Spectral domain optical coherence tomography (SD-OCT) is a non-invasive tool providing unprecedented imaging and analysis of vitreomacular interface. Two cases of vitreomacular traction were analysed by advanced three-dimensional (3D) SD-OCT imaging. En-face OCT permitted localisation of the exact point of attachment of vitreous to retina. A comprehensive view of the surface topography and anatomical configuration of vitreomacular affection was revealed by 3D imaging with segmentation technique. Macular change analysis programme revealed progression to full-thickness macular hole in the second case. Non-invasive high-resolution SD-OCT imaging has transformed the understanding and management of vitreomacular traction. Its role is further reinforced by the introduction of ocriplasmin for management of vitreomacular adhesions.
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