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Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

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Related Experiment Video

Updated: Apr 24, 2026

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

Enhanced long-term memory encoding after parietal neurostimulation.

Kevin T Jones¹, Filiz Gözenman, Marian E Berryhill

¹Program in Cognitive and Brain Sciences, Department of Psychology, University of Nevada, Reno, 1664 North Virginia Street, Mail Stop 296, Reno, NV, 89557, USA, KevJones22@gmail.com.

Experimental Brain Research

|September 10, 2014

Summary

This summary is machine-generated.

Transcranial direct current stimulation (tDCS) enhances long-term memory (LTM) when applied to the left posterior parietal cortex (PPC) during memory encoding in healthy adults.

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Area of Science:

Neuroscience
Cognitive Psychology
Neuromodulation

Background:

Neurostimulation techniques like transcranial direct current stimulation (tDCS) show potential for cognitive enhancement.
The posterior parietal cortex (PPC) plays a role in frontoparietal networks crucial for long-term memory (LTM).

Purpose of the Study:

To investigate if tDCS applied to the PPC can facilitate verbal LTM encoding and retrieval.
To determine the temporal and hemispheric specificity of tDCS effects on LTM.

Main Methods:

Healthy young adults performed a verbal LTM task (California Verbal Learning Task).
tDCS was applied to the left or right PPC during encoding, prior to retrieval, or during maintenance.
Stimulation parameters and timing were varied to assess specificity.

Main Results:

Anodal left PPC tDCS during LTM encoding improved learning speed and short-delay retrieval.
tDCS effects were specific to the encoding phase, not maintenance or retrieval.
Stimulation of the right PPC did not yield significant LTM improvements.

Conclusions:

Anodal tDCS to the left PPC can enhance verbal LTM in healthy young adults.
The timing of stimulation (during encoding) and the targeted hemisphere (left PPC) are critical for efficacy.