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Related Experiment Video

Updated: Apr 24, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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[Management of gliomas].

S Lévy1, S Chapet1, J-J Mazeron2

  • 1Service de radiothérapie oncologique, centre Henry-Kaplan, université François-Rabelais, CHRU de Tours, 2, boulevard Tonnelé, 37000 Tours, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 10, 2014
PubMed
Summary

This study reviews glioma treatments, highlighting surgery, chemoradiation, and novel therapies like bevacizumab. It discusses radiotherapy techniques and O(6)-methylguanine-DNA methyltransferase (MGMT) status for personalized glioma care.

Keywords:
GlioblastomaGlioblastomeGliomaGliomeIntensity modulation radiotherapyRadiothérapie conformationnelle avec modulation d’intensité

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Area of Science:

  • Neuro-oncology
  • Radiation oncology
  • Medical oncology

Background:

  • Gliomas are common primary brain tumors, posing treatment challenges due to their location near critical brain structures.
  • Current glioblastoma treatment involves surgery followed by Stupp et al. protocol chemoradiation.
  • Bevacizumab improves progression-free survival but not overall survival in glioblastoma, and is typically reserved for clinical trials.

Purpose of the Study:

  • To review current and emerging treatment strategies for various glioma types.
  • To discuss the role of radiotherapy techniques and molecular markers in glioma management.
  • To explore therapeutic options for recurrent gliomas and specific subtypes like anaplastic gliomas.

Main Methods:

  • Review of existing literature on glioma treatment protocols and clinical trials.
  • Analysis of the efficacy of different therapeutic modalities including surgery, chemotherapy, and radiotherapy.
  • Consideration of prognostic and predictive factors such as MGMT status and 1p19q mutation.

Main Results:

  • Intensity-modulated radiotherapy may reduce long-term neurocognitive effects.
  • Accelerated radiotherapy (40 Gy/15 fractions) shows comparable survival to standard radiotherapy in elderly patients.
  • Re-irradiation in stereotactic conditions offers a median survival of 8-12.4 months for recurrent gliomas.
  • Anaplastic gliomas with 1p19q mutation respond well to chemotherapy (procarbazine, lomustine, vincristine) and chemoradiotherapy.

Conclusions:

  • MGMT status can guide treatment decisions between chemotherapy and radiotherapy.
  • Chemoradiotherapy is the standard for 1p19q-mutated anaplastic gliomas.
  • Ongoing research focuses on targeted therapies and advanced radiotherapy techniques for gliomas.